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Molecular Profile | EML4 - ALK |
Therapy | THZ1 |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK | lung adenocarcinoma | sensitive | THZ1 | Preclinical - Cell culture | Actionable | In a preclinical study, THZ1 treatment reduced viability and inhibited proliferation of parental lung adenocarcinoma, and isogenic cells resistant to Xalkori (crizotinib), Zykadia (ceritinib), and Alecensa (alectinib) cells, all harboring EML4-ALK, in culture (PMID: 32558295). | 32558295 |
PubMed Id | Reference Title | Details |
---|---|---|
(32558295) | Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition. | Full reference... |