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Molecular Profile | IDH1 R132X |
Therapy | BAY1436032 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132X | acute myeloid leukemia | no benefit | BAY1436032 | Phase I | Actionable | In a Phase I trial, treatment with BAY1436032 in acute myeloid leukemia patients harboring an IDH1 R132X mutation demonstrated safety and resulted in an overall response rate of 15% (4/27), including one complete remission, one partial remission, and morphologic leukemia-free state in two patients, stable disease in 67% (18/27), and a median overall survival of 6.6 months, however, due to low response rates for all doses, further clinical development was not supported (PMID: 32733012; NCT03127735). | 32733012 |
PubMed Id | Reference Title | Details |
---|---|---|
(32733012) | Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results. | Full reference... |