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Molecular Profile FGFR1 amp FGFR1 over exp
Therapy Docetaxel + Rogaratinib
Indication/Tumor Type lung cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 amp FGFR1 over exp lung cancer sensitive Docetaxel + Rogaratinib Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with Rogaratinib (BAY 1163877) and Taxotere (docetaxel) resulted in an increased percentage of partial responses from 40% to 70% and one complete response compared to Taxotere (docetaxel) alone in lung cancer cell line xenograft models with FGFR1 amplification and FGFR1 overexpression (PMID: 30807645). 30807645
PubMed Id Reference Title Details
(30807645) Rogaratinib: A potent and selective pan-FGFR inhibitor with broad antitumor activity in FGFR-overexpressing preclinical cancer models. Full reference...