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Molecular Profile | FGFR1 over exp |
Therapy | Rogaratinib |
Indication/Tumor Type | lung cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 over exp | lung cancer | predicted - sensitive | Rogaratinib | Preclinical - Pdx | Actionable | In a preclinical study, a lung cancer patient-derived xenograft (PDX) model with FGFR1 overexpression demonstrated decreased tumor volume when treated with Rogaratinib (BAY 1163877) (PMID: 30807645). | 30807645 |
PubMed Id | Reference Title | Details |
---|---|---|
(30807645) | Rogaratinib: A potent and selective pan-FGFR inhibitor with broad antitumor activity in FGFR-overexpressing preclinical cancer models. | Full reference... |