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Molecular Profile | TP53 I255N |
Therapy | thioureidobutyronitrile |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 I255N | acute myeloid leukemia | predicted - sensitive | thioureidobutyronitrile | Preclinical - Patient cell culture | Actionable | In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis of leukemic blast cells and decreased cell viability in patient-derived acute myeloid leukemia cells harboring TP53 I255N in culture (PMID: 32945487). | 32945487 |
PubMed Id | Reference Title | Details |
---|---|---|
(32945487) | Kevetrin induces apoptosis in TP53 wild‑type and mutant acute myeloid leukemia cells. | Full reference... |