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Molecular Profile | PTEN L152P PTEN neg |
Therapy | AZD8186 |
Indication/Tumor Type | salivary gland carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN L152P PTEN neg | salivary gland carcinoma | resistant | AZD8186 | Preclinical - Cell culture | Actionable | In a preclinical study, salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression were resistant to AZD8186-induced inhibition of Akt phosphorylation and proliferation in culture (PMID: 30289966). | 30289966 |
PubMed Id | Reference Title | Details |
---|---|---|
(30289966) | Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. | Full reference... |