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Molecular Profile | PTEN L152P PTEN neg |
Therapy | Pictilisib |
Indication/Tumor Type | salivary gland carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN L152P PTEN neg | salivary gland carcinoma | sensitive | Pictilisib | Preclinical - Cell culture | Actionable | In a preclinical study, Pictilisib (GDC-0941) inhibited Akt phosphorylation and proliferation of salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression in culture (PMID: 30289966). | 30289966 |
PubMed Id | Reference Title | Details |
---|---|---|
(30289966) | Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. | Full reference... |