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Molecular Profile | NRAS Q61K |
Therapy | Chelidonine |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS Q61K | melanoma | sensitive | Chelidonine | Preclinical - Cell culture | Actionable | In a preclinical study, Chelidonine treatment inhibited activation of Nras and downstream signaling pathways, reduced proliferation and colony formation, and induced apoptosis in melanoma cells harboring NRAS Q61K in culture (PMID: 32156748). | 32156748 |
PubMed Id | Reference Title | Details |
---|---|---|
(32156748) | Targeting NRAS-Mutant Cancers with the Selective STK19 Kinase Inhibitor Chelidonine. | Full reference... |