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| Molecular Profile | BRAF wild-type |
| Therapy | Vemurafenib |
| Indication/Tumor Type | melanoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF wild-type | melanoma | no benefit | Vemurafenib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Zelboraf (vemurafenib) treatment did not inhibit viability of patient-derived wild-type BRAF melanoma cells in culture (PMID: 23715574). | 23715574 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23715574) | Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. | Full reference... |