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Molecular Profile | BRAF wild-type |
Therapy | Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF wild-type | melanoma | no benefit | Vemurafenib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Zelboraf (vemurafenib) treatment did not inhibit viability of patient-derived wild-type BRAF melanoma cells in culture (PMID: 23715574). | 23715574 |
PubMed Id | Reference Title | Details |
---|---|---|
(23715574) | Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma. | Full reference... |