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| Molecular Profile | BRAF G469E |
| Therapy | Sorafenib |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF G469E | melanoma | sensitive | Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Nexavar (sorafenib) treatment induced apoptosis and mitochondrial depolarization, and inhibited growth of melanoma cells harboring BRAF G469E in culture (PMID: 18794803). | 18794803 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18794803) | CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations. | Full reference... |