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Molecular Profile | BRAF K601E |
Therapy | Sorafenib |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF K601E | melanoma | predicted - sensitive | Sorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Nexavar (sorafenib) treatment induced limited apoptosis and inhibited growth of melanoma cells harboring BRAF K601E in culture (PMID: 18794803). | 18794803 |
PubMed Id | Reference Title | Details |
---|---|---|
(18794803) | CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations. | Full reference... |