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| Molecular Profile | RAD51B wild-type |
| Therapy | N/A |
| Indication/Tumor Type | breast cancer |
| Response Type | not applicable |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RAD51B wild-type | breast cancer | not applicable | N/A | Preclinical | Emerging | SiRNA inhibition of RAD51B in breast cancer cells resulted in increased sensitivity to DNA damaging agents in culture, suggesting that RAD51B could be a promising therapeutic target for sensitization to chemotherapeutic agents in combination therapies (PMID: 25368520). | 25368520 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25368520) | RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines. | Full reference... |