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| Molecular Profile | ARID1A loss |
| Therapy | Berzosertib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ARID1A loss | colorectal cancer | sensitive | Berzosertib | Preclinical - Cell culture | Actionable | In a preclinical study, Berzosertib (VX-970) inhibited viability of a colorectal cancer cell line harboring ARID1A loss in culture (PMID: 29038346). | 29038346 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29038346) | ATR Is a Therapeutic Target in Synovial Sarcoma. | Full reference... |