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Molecular Profile | HRAS inact mut |
Therapy | Dactolisib |
Indication/Tumor Type | thyroid cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS inact mut | thyroid cancer | sensitive | Dactolisib | Preclinical | Actionable | In a preclinical study, BEZ235 inhibited growth of thyroid cancer cells harboring an HRAS pathway activating mutation in cell culture (PMID: 21831957). | 21831957 |
PubMed Id | Reference Title | Details |
---|---|---|
(21831957) | Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer. | Full reference... |