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Molecular Profile | APC inact mut |
Therapy | Sulindac |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colorectal cancer | sensitive | Sulindac | Preclinical | Actionable | In a preclinical study, colorectal cancer mouse models carrying APC inactivating mutations had reduced intestinal tumor burden after treatment with Clinoril (sulindac) (PMID: 19755659). | 19755659 |
PubMed Id | Reference Title | Details |
---|---|---|
(19755659) | Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. | Full reference... |