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| Molecular Profile | APC inact mut |
| Therapy | Dasatinib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colorectal cancer | sensitive | Dasatinib | Preclinical | Actionable | In a preclinical study, the combination of Sprycel (dasatinib) and curcumin inhibited tumor growth in a mouse model of colorectal cancer harboring an Apc mutation (PMID: 20473900). | 20473900 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20473900) | Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. | Full reference... |