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Molecular Profile | APC inact mut |
Therapy | Dasatinib |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colorectal cancer | sensitive | Dasatinib | Preclinical | Actionable | In a preclinical study, the combination of Sprycel (dasatinib) and curcumin inhibited tumor growth in a mouse model of colorectal cancer harboring an Apc mutation (PMID: 20473900). | 20473900 |
PubMed Id | Reference Title | Details |
---|---|---|
(20473900) | Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells. | Full reference... |