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| Molecular Profile | APC inact mut |
| Therapy | CGP049090 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colon cancer | sensitive | CGP049090 | Preclinical | Actionable | In a preclinical study, CGP049090 inhibited proliferation of a colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). | 14749129 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (14749129) | Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. | Full reference... |