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Molecular Profile | APC inact mut |
Therapy | CGP049090 |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colon cancer | sensitive | CGP049090 | Preclinical | Actionable | In a preclinical study, CGP049090 inhibited proliferation of a colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). | 14749129 |
PubMed Id | Reference Title | Details |
---|---|---|
(14749129) | Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. | Full reference... |