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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK K433T | lymphoma | sensitive | Ibrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, a lymphoma cell line expressing BTK K433T was sensitive to Imbruvica (ibrutinib) treatment in culture, demonstrating decreased cell viability (PMID: 33419778). | 33419778 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33419778) | Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation. | Full reference... |