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| Molecular Profile | APC inact mut |
| Therapy | ICG-001 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colon cancer | sensitive | ICG-001 | Preclinical | Actionable | In a preclinical study, ICG-001 decreased cell proliferation in colon cancer cell lines and in mouse models carrying APC inactivating mutations (PMID: 15314234). | 15314234 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (15314234) | A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. | Full reference... |