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| Molecular Profile | APC inact mut |
| Therapy | MF tricyclic |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colon cancer | sensitive | MF tricyclic | Preclinical | Actionable | In a preclinical study, mouse models of colon cancer carrying an APC 716del mutation had reduced polyp formation after treatment with MF tricyclic (PMID: 23843721). | 23843721 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23843721) | Recent progress in mouse models for tumor suppressor genes and its implications in human cancer. | Full reference... |