Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | APC inact mut |
| Therapy | PKF115-584 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | colon cancer | sensitive | PKF115-584 | Preclinical | Actionable | In a preclinical study, PKF115-584 inhibited proliferation of colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). | 14749129 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (14749129) | Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. | Full reference... |