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Molecular Profile | FGFR2 amp |
Therapy | Dovitinib |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | breast cancer | sensitive | Dovitinib | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Dovitinib (TKI258) inhibited cell growth of an FGFR2 amplified breast cancer cell line in culture and prevented tumor growth and induced tumor regression in FGFR2 amplified breast cancer patient derived xenograft (PDX) models (PMID: 23658459). | 23658459 |
PubMed Id | Reference Title | Details |
---|---|---|
(23658459) | Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. | Full reference... |