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| Molecular Profile | NRAS Q61K |
| Therapy | YM-254890 |
| Indication/Tumor Type | uveal melanoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61K | uveal melanoma | no benefit | YM-254890 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed mouse melanocytes expressing NRAS Q61K were insensitive to treatment with YM-254890 (PMID: 33229459). | 33229459 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33229459) | Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. | Full reference... |