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Molecular Profile | BRAF V600E |
Therapy | Trametinib + YM-254890 |
Indication/Tumor Type | skin melanoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | skin melanoma | no benefit | Trametinib + YM-254890 | Preclinical - Cell culture | Actionable | In a preclinical study, combination treatment with YM-254890 and Mekinist (trametinib) did not result in synergistic inhibition of cell viability of a cutaneous melanoma cell line harboring BRAF V600E in culture (PMID: 33229459). | 33229459 |
PubMed Id | Reference Title | Details |
---|---|---|
(33229459) | Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. | Full reference... |