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Molecular Profile | TP53 wild-type |
Therapy | SAR405838 |
Indication/Tumor Type | acute leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | acute leukemia | sensitive | SAR405838 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SAR405838 inhibited growth of TP53 wild-type acute leukemia cells in culture and resulted in tumor regression in cell line xenograft models (PMID: 25145672). | 25145672 |
PubMed Id | Reference Title | Details |
---|---|---|
(25145672) | SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. | Full reference... |