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| Molecular Profile | TP53 wild-type |
| Therapy | SAR405838 |
| Indication/Tumor Type | prostate cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 wild-type | prostate cancer | sensitive | SAR405838 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SAR405838 inhibited growth of TP53 wild-type prostate cancer cells in culture and resulted in tumor regression in cell line xenograft models (PMID: 25145672). | 25145672 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25145672) | SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. | Full reference... |