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| Molecular Profile | PIK3CA H1047R |
| Therapy | PF-04691502 |
| Indication/Tumor Type | ovarian cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047R | ovarian cancer | sensitive | PF-04691502 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PF-04691502 inhibited Pi3k signaling, resulted in growth inhibition of ovarian cancer cells harboring PIK3CA H1047R in culture and in cell line xenograft models (PMID: 21750219). | 21750219 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21750219) | PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. | Full reference... |