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Molecular Profile | JAK2 V617F |
Therapy | Go6976 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | acute myeloid leukemia | sensitive | Go6976 | Preclinical | Actionable | In a preclinical study, Go 6976 inhibited proliferation of cultured acute myeloid leukemia cells expressing the JAK2 V617F mutation (PMID: 16956345). | 16956345 |
PubMed Id | Reference Title | Details |
---|---|---|
(16956345) | Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. | Full reference... |