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Molecular Profile BRAF V600E
Therapy Dabrafenib + SCH772984
Indication/Tumor Type thyroid cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E thyroid cancer sensitive Dabrafenib + SCH772984 Preclinical - Cell line xenograft Actionable In a preclinical study, combination treatment with Tafinlar (dabrafenib) and SCH772984 synergistically inhibited cell growth of thyroid cancer cell lines harboring BRAF V600E in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33595872). 33595872
PubMed Id Reference Title Details
(33595872) Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo. Full reference...