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Molecular Profile | EML4 - ALK TP53 V274fs |
Therapy | Alectinib + Ixazomib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK TP53 V274fs | lung non-small cell carcinoma | sensitive | Alectinib + Ixazomib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination therapy of Alecensa (alectinib) and Ninlaro (ixazomib) inhibited the proliferation of non-small cell lung cancer cells harboring EML4-ALK and TP53 Q331* in culture and resulted in tumor regression in cell line xenograft models, with 3/8 achieving complete tumor regression (PMID: 33310890). | 33310890 |
PubMed Id | Reference Title | Details |
---|---|---|
(33310890) | Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression. | Full reference... |