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Molecular Profile TP53 Y220C
Therapy PC14586
Indication/Tumor Type stomach cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Y220C stomach cancer predicted - sensitive PC14586 Preclinical - Cell line xenograft Actionable In a preclinical study, PC14586 treatment reactivated Tp53 function, resulted in 80% tumor regression after 3 weeks in cell line xenograft models of gastric cancer harboring TP53 Y220C (AACR Annual Meeting Apr 2021, Session MS.LBA01, Abstract # LB006). detail...
PubMed Id Reference Title Details
PC14586: The first orally bioavailable small molecule reactivator of Y220C mutant p53 in clinical development Full reference...