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| Molecular Profile | RET C634W |
| Therapy | Lenvatinib |
| Indication/Tumor Type | thyroid cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634W | thyroid cancer | sensitive | Lenvatinib | Preclinical | Actionable | In a preclinical study, Lenvima (lenvatinib) inhibited RET phosphorylation and signaling in thyroid cancer cells expressing RET C634W (PMID: 25295214). | 25295214 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25295214) | Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models. | Full reference... |