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| Molecular Profile | TP53 D281G |
| Therapy | AZ32 + Radiotherapy |
| Indication/Tumor Type | high grade glioma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 D281G | high grade glioma | sensitive | AZ32 + Radiotherapy | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZ32 treatment increased sensitivity to radiotherapy in malignant glioma cells harboring TP53 D281G, resulting in significantly increased survival (P=0.0015) in intracranial cell line xenograft models compared to radiotherapy alone (PMID: 29769307). | 29769307 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29769307) | Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. | Full reference... |