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Molecular Profile | BRAF V600E |
Therapy | Ruxolitinib + Vemurafenib |
Indication/Tumor Type | hairy cell leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | hairy cell leukemia | predicted - sensitive | Ruxolitinib + Vemurafenib | Phase II | Actionable | In a Phase II trial (HCL-PG03), combined Zelboraf (vemurafenib) and Jakafi (ruxolitinib) therapy in relapsed or refractory hairy cell leukemia patients with BRAF V600E demonstrated safety, and led to complete response (CR) in 87% (26/30) of patients, including 17 (65%) with negative minimal residual disease, a progression-free survival rate of 78% at a median follow-up of 37 months, and a relapse-free survival rate of 85% in the 26 patients with a CR at a median follow-up of 34 months (PMID: 33979489). | 33979489 |
PubMed Id | Reference Title | Details |
---|---|---|
(33979489) | Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia. | Full reference... |