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Molecular Profile NRAS Q61L
Therapy Belvarafenib + Cobimetinib
Indication/Tumor Type melanoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS Q61L melanoma sensitive Belvarafenib + Cobimetinib Preclinical - Cell line xenograft Actionable In a preclinical study, the addition of Cotellic (cobimetinib) to treatment with Belvarafenib (HM95573) in melanoma cell lines harboring NRAS Q61L resulted in greater inhibition of cell proliferation in culture compared to single agent alone, and led to decreased tumor volume, with increased efficacy and response durability in a cell line xenograft model (PMID: 33953400). 33953400
PubMed Id Reference Title Details
(33953400) ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. Full reference...