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| Molecular Profile | FLT3 exon 14 ins FLT3 F691L |
| Therapy | KX2-391 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 F691L | hematologic cancer | sensitive | KX2-391 | Preclinical | Actionable | In a preclinical study, KX2-391 treatment inhibited viability, decreased downstream signaling, and induced apoptosis in cells expressing a FLT3-ITD mutation with FLT3 F691L in culture, and inhibited tumor growth and prolonged survival in mouse models (PMID: 34217323). | 34217323 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34217323) | A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia. | Full reference... |