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| Molecular Profile | NRAS Q61K |
| Therapy | Belvarafenib |
| Indication/Tumor Type | melanoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61K | melanoma | predicted - sensitive | Belvarafenib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Belvarafenib (HM95573) treatment led to inhibition of tumor growth in a melanoma cell line xenograft model harboring NRAS Q61K (PMID: 33953400). | 33953400 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33953400) | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. | Full reference... |