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Molecular Profile ERBB3 positive
Therapy ISU104
Indication/Tumor Type head and neck squamous cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 positive head and neck squamous cell carcinoma sensitive ISU104 Preclinical - Cell line xenograft Actionable In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in head and neck squamous carcinoma cell lines in culture, and resulted in tumor regression in cell line xenograft models (PMID: 33782100). 33782100
PubMed Id Reference Title Details
(33782100) A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization. Full reference...