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| Molecular Profile | ERBB3 positive |
| Therapy | ISU104 |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | head and neck squamous cell carcinoma | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in head and neck squamous carcinoma cell lines in culture, and resulted in tumor regression in cell line xenograft models (PMID: 33782100). | 33782100 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33782100) | A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization. | Full reference... |