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Molecular Profile | FLT3 exon 14 ins FLT3 D835Y |
Therapy | KX2-391 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 D835Y | acute myeloid leukemia | predicted - sensitive | KX2-391 | Preclinical - Patient cell culture | Actionable | In a preclinical study, KX2-391 treatment inhibited cell viability and decreased Flt3 phosphorylation in patient-derived acute myeloid leukemia cell lines harboring a FLT3-ITD mutation with FLT3 D835Y in culture (PMID: 34217323). | 34217323 |
PubMed Id | Reference Title | Details |
---|---|---|
(34217323) | A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia. | Full reference... |