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Molecular Profile BRAF T119S BRAF V600E
Therapy LY3214996
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF T119S BRAF V600E colorectal cancer predicted - sensitive LY3214996 Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line harboring BRAF V600E and BRAF T119S was sensitive to treatment with LY3214996 in culture, demonstrating decreased cell proliferation (PMID: 31744895). 31744895
PubMed Id Reference Title Details
(31744895) ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine. Full reference...