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| Molecular Profile | BRAF V600E |
| Therapy | Dabrafenib + Rabeprazole + Rifampin + Trametinib |
| Indication/Tumor Type | endometrial adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | endometrial adenocarcinoma | predicted - sensitive | Dabrafenib + Rabeprazole + Rifampin + Trametinib | Case Reports/Case Series | Actionable | In a Phase I trial, the addition of Mekinist (trametinib) to combination treatment with Tafinlar (dabrafenib), Rabeprazole, and Rifampin resulted in a maintained radiographic response of lung metastases and stable pelvic mass size in a patient with metastatic endometrial adenocarcinoma harboring BRAF V600E, which lasted for 12 months (PMID: 33537843; NCT01954043). | 33537843 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33537843) | BRAF/MEK inhibitors for BRAF V600E-mutant cancers in non-approved setting: a case series. | Full reference... |