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Molecular Profile FLT3 I836del
Therapy Azacitidine + Sorafenib + Venetoclax
Indication/Tumor Type acute myeloid leukemia
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 I836del acute myeloid leukemia predicted - sensitive Azacitidine + Sorafenib + Venetoclax Case Reports/Case Series Actionable In a clinical study, combination treatment with Vidaza (azacitidine), Nexavar (sorafenib) and Venclexta (venetoclax) resulted in continued remission from Cytosar-U (cytarabine), Novantrone (mitoxantrone), and Nexavar (sorafenib) treatment in an acute myeloid leukemia patient harboring FLT3 I836del (PMID: 33563661; NCT02670525). 33563661
PubMed Id Reference Title Details
(33563661) Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. Full reference...