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Molecular Profile | RET M918T |
Therapy | Pz-1 |
Indication/Tumor Type | medullary thyroid carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET M918T | medullary thyroid carcinoma | sensitive | Pz-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Pz-1 treatment inhibited downstream signaling and growth of a medullary thyroid carcinoma cell line harboring RET M918T in culture, and inhibited tumor growth in cell line xenograft models (PMID: 34373541). | 34373541 |
PubMed Id | Reference Title | Details |
---|---|---|
(34373541) | Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases. | Full reference... |