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Molecular Profile EML4 - ALK
Therapy Alectinib
Indication/Tumor Type papillary renal cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK papillary renal cell carcinoma predicted - sensitive Alectinib Case Reports/Case Series Actionable In a clinical study, three previously treated patients with metastatic papillary renal cell carcinoma harboring an EML4-ALK fusion were sensitive to treatment with Alecensa (alectinib), demonstrating a clinical and radiographic response in one patient, a radiographic response and ongoing stable disease for 9 months in another patient, and regression of multiple metastatic sites in the third patient (PMID: 29685646). 29685646
PubMed Id Reference Title Details
(29685646) Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma. Full reference...