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Molecular Profile | KEAP1 D236H |
Therapy | Osimertinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KEAP1 D236H | lung non-small cell carcinoma | resistant | Osimertinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) harbored the KEAP1 D236H mutation and also demonstrated resistance to Tagrisso (osimertinib) in culture (PMID: 29812969). | 29812969 |
PubMed Id | Reference Title | Details |
---|---|---|
(29812969) | Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells. | Full reference... |