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| Molecular Profile | FGFR1 K656E |
| Therapy | Infigratinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | conflicting |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 K656E | Advanced Solid Tumor | conflicting | Infigratinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR1 K656E demonstrated insensitivity to Truseltiq (infigratinib) in culture (PMID: 34114373). | 34114373 |
| FGFR1 K656E | Advanced Solid Tumor | conflicting | Infigratinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR1 K656E were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). | 34272467 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34272467) | Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. | Full reference... |
| (34114373) | GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. | Full reference... |