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Molecular Profile JAK2 LOH JAK2 inact mut
Therapy HSV1-dICP0
Indication/Tumor Type melanoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 LOH JAK2 inact mut melanoma predicted - sensitive HSV1-dICP0 Preclinical - Patient cell culture Actionable In a preclinical study, a melanoma patient-derived cell line harboring an inactivating JAK2 mutation and JAK2 loss of heterozygosity resulted in sensitivity to treatment with an oncolytic virus, HSV1-dICP0, in culture (PMID: 33593882). 33593882
PubMed Id Reference Title Details
(33593882) Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment. Full reference...