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| Molecular Profile | RB1 loss |
| Therapy | LY3295668 |
| Indication/Tumor Type | Merkel cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RB1 loss | Merkel cell carcinoma | sensitive | LY3295668 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, LY3295668 resulted in cell growth inhibition and increased cell cycle arrest and apoptosis in Merkel cell carcinoma patient-derived cell lines with loss of Rb1 expression in culture, and resulted in reduced tumor growth in a patient-derived xenograft (PDX) model (PMID: 34359608). | 34359608 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34359608) | Selective Inhibition of Aurora Kinase A by AK-01/LY3295668 Attenuates MCC Tumor Growth by Inducing MCC Cell Cycle Arrest and Apoptosis. | Full reference... |