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| Molecular Profile | FLT3 exon 14 ins FLT3 N701K |
| Therapy | Gilteritinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 N701K | hematologic cancer | resistant | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing FLT3-ITD and FLT3 N701K demonstrated resistance to treatment with Xospata (gilteritinib) in culture (PMID: 33780043). | 33780043 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33780043) | A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance. | Full reference... |