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Molecular Profile | PTEN loss |
Therapy | Carboplatin + Paclitaxel + Sapanisertib |
Indication/Tumor Type | prostate cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | prostate cancer | predicted - sensitive | Carboplatin + Paclitaxel + Sapanisertib | Case Reports/Case Series | Actionable | In a Phase I trial, combination treatment with Paraplatin (carboplatin), Taxol (paclitaxel), and Sapanisertib (MLN0128) led to a partial response in a castrate resistant prostate cancer harboring PTEN loss (Cancer Res 2021;81(13_Suppl):Abstract nr CT109; NCT03430882). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Phase I study of mTORC1-2 inhibitor sapanisertib (TAK-228) in combination with carboplatin plus paclitaxelin patients with advanced solid malignancies and mTOR pathway alterations | Full reference... |